Publications

Allison McKenzie Johnson, Charles Froman-Glover, Akshitkumar Mistry, Kavitha Yaddanapudi, Joseph Chen,”The impact of compression and confinement in tumor growth and progression: new insights in cancer mechanobiology”, Frontiers in Materials 12, p.1492438; 2025

Bradley J Mahaffey*, Zachary P Fowler*, Zoe Lung, Vivien Dang, Hyun-chul Lee, Allison McKenzie Johnson, Dylan A. Goodin, Hermann Frieboes, Brian J. Johnson, Joseph Chen, “The prognostic effect of mechanical, ultrastructural, and ECM signatures in glioblastoma core and rim.” APL Bioeng. 8, 036101; 2024

Akshitkumar M. Mistry, Jonah Daneshmand, SeonYeong Jamie Seo, Norman L. Lehman, Donald M. Miller, Dylan A. Goodin, Hermann B. Frieboes, Joseph Chen, Adrianna Masters, Brian J. Williams, MD, and Kavitha Yaddanapudi, “Spatially Resolved Microglia in Recurrent Glioblastomas Overexpress Fatty Acid Metabolism and Phagocytic Genes”, Curr. Oncol. 2024, 31(3), 1183-1194

Landon Teer, Kavitha Yaddanapudi, Joseph Chen, “Biophysical control of the glioblastoma immunosuppressive microenvironment: opportunities for immunotherapy”, Bioengineering. 2024; 11(1):93

Donald M Miller, Kavitha Yadanapudi, Veeresh Rai, Shesh N Rai, Joseph Chen, Hermann B Frieboes, Adrianna Masters, Abigail McCallum, Brian J Williams, “Untangling the web of glioblastoma treatment resistance using a multi-omic and multidisciplinary approach”, The American Journal of the Medical Sciences, 2023

Mary E Baxter, Hunter A Miller, Joseph Chen, Brian J Williams, Hermann B Frieboes, “Metabolomic differentiation of tumor core versus edge in glioma”, Neurosurgical Focus, 54:6, E4; 2023

Müge Sak, Brian J. Williams, Cory T. Zumbar, Landon Teer, Mustafa N. G. Al-Kawaaz, Aastha Kakar, Andrew J. Hey, Megan J. Wilson, Leslie M. Schier, Joseph Chen and Norman L. Lehman, “The CNS-penetrating taxane drug TPI 287 potentiates antiglioma activity of the AURKA inhibitor alisertib in vivo”, Cancer Chemotherapy and Pharmacology; 2022

Christine Kim, Joseph Chen, Brian P Ceresa, “Chronic Arsenic Increases Cell Migration in BEAS-2B Cells by Increasing Cell Speed, Cell Persistence, and Cell Protrusion Length”, Experimental Cell Research, 408, 1, 112852; 2021

Joseph Chen, Hyunchul Lee, Philipp Schmitt, Caleb J Choy, Donald M Miller, Brian J Williams, Elaine L Bearer, Hermann B Frieboes, Bioengineered Models to Study Microenvironmental Regulation of Glioblastoma Metabolism, Journal of Neuropathology & Experimental Neurology, 2021;, nlab092

Pre-UofL

Joseph Chen*, Badri A. Ananthanarayanan*, Kelsey S. Springer, Kayla J. Wolf, Sharon M. Sheyman, Vivien D. Tran, Sanjay Kumar, “Suppression of LIM Kinase 1 and 2 Limits Glioblastoma Invasion”, Cancer Research, 80(1):69-78; 2020.

Kayla Wolf, Joseph Chen, Jason Coombes, Manish Aghi, Sanjay Kumar, “Dissecting and Rebuilding the Glioblastoma Microenvironment with Engineered Materials”, Nature Reviews Materials, 4, 651-668; 2019.

Joseph Chen, Sourav Patnaik, Raj Prabu, Lauren B. Priddy, Jean-Luc Bouvard, Esteban Marin, Mark F. Horstemeyer, Jun Liao, Lakiesha N. Williams, “Mechanical Response of Porcine Liver Tissue under High Strain Rate Compression”, Bioengineering 6(2), 49; 2019.

Jasmine H. Hughes, Jeanette M. Ewy, Joseph Chen, Sophie Y. Wong, Kevin M. Tharp, Andreas Stahl, Sanjay Kumar, “Transcriptomic Analysis Reveals That BMP4 Sensitizes Glioblastoma Tumor-Initiating Cells to Mechanical Cues”, Matrix Biology, 2019.

Joseph Chen, Bryn Brazile, Raj Prabhu, Sourav Patnaik, Robbin Bertucci, Hongjoo Rhee, Mark F. Horstemeyer, Yi Hong, Lakiesha N. Williams, Jun Liao, “Quantitative Analysis of Tissue Damage Evolution in Porcine Liver with Interrupted Mechanical Testing under Tension, Compression, and Shear”, Journal of Biomechanical Engineering, 140(7); 2018.

Joseph Chen, Sanjay Kumar, “Biophysical Regulation of Cancer Stem/Initiating Cells: Implications of Disease Mechanisms and Translation”, Current Opinions in Biomedical Engineering, 1:87-95; 2017.

John Clemmer, Raj Prabhu, Joseph Chen, Erin Colebeck, Lauren B. Priddy, Michael McCollum, Bryn Brazile, Wilbur Whittington, Jennifer L. Wardlaw, Hongjoo Rhee, Mark F. Horstemeyer, Lakiesha N. Williams, Jun Liao, “Experimental Observation of High Strain Rate Responses of Porcine Brain, Liver, and Tendon”, Journal of Mechanics in Medicine and Biology, 16(3); 2016.

Joseph Chen, Larisa M. Ryzhova, M.K. Sewell-Loftin, Christopher B. Brown, H. Scott Baldwin, W. David Merryman, “Notch1 Mutation Leads to Valvular Calcification through Enhanced Cadherin-11 Mechanotransduction”, Arteriosclerosis, Thrombosis, and Vascular Biology, 35(7):1597-605; 2015.

Joseph Chen, Jon R. Peacock, Janelle Branch, W. David Merryman, “Biophysical Analysis of in vitro Models of Valvular Calcification”, Journal of Biomechanical Engineering, 137(2); 2015.

Joseph Chen, Beth A. Drzewiecki, W. David Merryman, John C. Pope 4th, “Murine Bladder Compliance Changes Following Partial Bladder Outlet Obstruction”, Journal of Biomechanics, 46(15): 2752-5; 2013.

Joshua D. Hutcheson*, Joseph Chen*, M.K. Sewell-Loftin, Larisa M. Ryzhova, Charles I. Fisher, Yan R. Su, W. David Merryman, “Cadherin-11 Regulates Cell-Cell Tension Necessary for Calcific Nodule Formation by Valvular Myofibroblasts.” Arteriosclerosis, Thrombosis, and Vascular Biology, 33: p 114-120; 2013.

Charles I. Fisher*, Joseph Chen*, W. David Merryman, “Calcific nodule morphogenesis by heart valve interstitial cells is strain-dependent”, Biomechanics and Modeling in Mechanobiology,12(1): 5-17; 2012.

Dan T. Simionescu, Joseph Chen, Michael Jaeggli, Bo Wang, Jun Liao, “Form Follows Function: Advances in Trilayered Structure Replication for Aortic Heart Valve Tissue Engineering”, Journal of Health Care Engineering. 3(2):179-202; 2012.

Jianjun Guan, Feng Wang, Zhenqing Li, Joseph Chen, Xiaolei Guo, Jun Liao, Nicanor I. Moldovan, “The Stimulation of the Cardiac Differentiation of Mesenchymal Stem Cells in Tissue Constructs that Mimic Myocardium Structure and Biomechanics”, Biomaterials. 32; 5568-5580; 2011.

Mary E. Tedder, Agneta Simionescu, Joseph Chen, Jun Liao, Dan T. Simionescu., Assembly and Testing of Stem Cell-Seeded Layered Collagen Constructs for Heart Valve Tissue Engineering. Tissue Engineering Part A. 17(1-2): p 25-36; 2011.

Leslie Sierad, Agneta Simionescu, Christopher Albers, Joseph Chen, Jordan Maivlett, Mary E. Tedder, Jun Liao, Dan T. Simionescu, “Design and Testing of a Pulsatile Conditioning System for Dynamic Endothelialization of Polyphenol-stabilized Tissue Engineered Heart Valves.” Cardiovascular Engineering and Technology. 1(2): p. 138-153; 2010.

Song Zhang, John A. Crow, Xiaoyong Yang, Joseph Chen, Ronald M. McLaughlin, Robert C. Cooper, Katie B. Mullins, Ali Borazjani, and Jun Liao, “The Correlation of 3D DT-MRI Fiber Disruption with Structural and Mechanical Degeneration in Porcine Myocardium.” Annals of Biomedical Engineering. 38(10): p. 3084-95; 2010.

James Warnock, Carol Pregonero Gamez, Scott Metzler, Joseph Chen, Steven Elder, and Jun Liao. “Vasoactive Agents Alter the biomechanical Properties of Aortic Heart Valve Leaflets in a Time-dependent Manner.” Journal of Heart Valve Disease. 19(1):86-95; 2010.

Jun Liao, Lauren B. Priddy, Bo Wang, Joseph Chen, and Ivan Vesely. “Ultrastructure of Porcine Mitral Valve Chordae Tendineae.” Journal of Heart Valve Disease. 18(3) 292-299, 2009.

* = co-first authorship